we have 2 anticoagulant
HEPARIN
- large molec means it cannot cross placenta hence can be given to pregnant lady
- can b given eithe sc or iv
- work as co factor -> heparin bind to antithrombin -> antithrombin change it configuration -> AT bind to thrombin -> making thrombin inact due to AT n heparin complex
- 2 types - low molec weight LMW n high molec weight HMW
- LMW -> high DOA , inhibit xpecially factor Xa, example enoxaparin
- HMW -> increase AT actvt n inhibit xpecially fact IIa n Xa
- adverse effect -> haemorrhage (antidote=protamine)/hypersensitivity/trombocytopenia
to be continued....
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