anticoagulant 1 :heparin:

we have 2 anticoagulant

HEPARIN

• large molec means it cannot cross placenta hence can be given to pregnant lady
• can b given eithe sc or iv
• work as co factor -> heparin bind to antithrombin -> antithrombin change it configuration -> AT bind to thrombin -> making thrombin inact due to AT n heparin complex
• 2 types - low molec weight LMW n high molec weight HMW
• LMW -> high DOA , inhibit xpecially factor Xa, example enoxaparin
• HMW -> increase AT actvt n inhibit xpecially fact IIa n Xa
• adverse effect -> haemorrhage (antidote=protamine)/hypersensitivity/trombocytopenia

to be continued....